Overview
Retatrutide (LY3437943) is a novel investigational peptide that acts as a simultaneous agonist at three incretin-related receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and the glucagon receptor. This tri-agonist profile distinguishes it from earlier single- or dual-receptor agents and has made it a subject of intense preclinical and clinical metabolic research.
In published Phase 2 clinical data, retatrutide demonstrated substantial effects on body weight and cardiometabolic markers over 48 weeks. Its multi-receptor engagement is hypothesized to provide complementary and potentially synergistic effects on energy intake, energy expenditure, hepatic glucose output, and adipose tissue metabolism.
Mechanism of Research Interest
Retatrutide's tri-agonist pharmacology targets three G-protein coupled receptors:
- GLP-1R agonism: promotes glucose-dependent insulin secretion, slows gastric emptying, and reduces caloric intake via central satiety signaling
- GIPR agonism: augments insulin secretion and may modulate central appetite regulation and adipocyte function
- Glucagon receptor agonism: increases hepatic glucose output and energy expenditure via thermogenesis, counterbalanced metabolically by the GLP-1/GIP arms
- Net effect in research models: pronounced reductions in fat mass, improved insulin sensitivity, and favorable lipid profiles
Technical Specifications
| Full Name | Retatrutide (LY3437943) |
| Receptor Targets | GLP-1R / GIPR / GcgR (triple agonist) |
| Molecular Formula | C₂₁₄H₃₃₁N₅₅O₆₅ |
| Molecular Weight | ~4,786 Da |
| Purity | ≥98% (HPLC verified) |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Storage (lyophilized) | −20°C, protected from light |
| Storage (reconstituted) | 2–8°C, use within 4 weeks |
| Solubility | Sterile water or bacteriostatic water |
Reconstitution Guidelines
Reconstitute with sterile or bacteriostatic water. Add solvent slowly along the inside wall of the vial — do not vortex or shake vigorously. Allow to dissolve at room temperature. Once reconstituted, store at 2–8°C and use within 4 weeks. Do not freeze reconstituted solution.
Quality & Documentation
Every batch of Retatrutide supplied by Trusty Peptide undergoes third-party HPLC testing to verify purity of ≥98%. A Certificate of Analysis (COA) detailing the batch number, test results, and molecular confirmation is included with every order and available on request prior to purchase.
Research Use Only. Retatrutide supplied by Trusty Peptide is intended strictly for laboratory and in vitro research purposes. It is not approved for human or veterinary use, and is not a medicine, drug, or nutritional supplement. By purchasing you confirm you are a qualified researcher using this compound for legitimate scientific research only.